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Table 2 Biochemical parameters of male rats receiving melittin post isoniazid and rifampicin-induced hepatotoxicity

From: Hepatoprotective activity of melittin on isoniazid- and rifampicin-induced liver injuries in male albino rats

  NC T Mel15 Mel30 NR
DB (μmol/l) 1.0 ± 0.451 7.05 ± 1.84a**** 1.0 ± 0.38b**** 1.0 ± 0.27 b**** 1.0 ± 0.31b****
TB (μmol/l) 1.6 ± 0.94 10.45 ± 2.13a**** 2 ± 1.05b**** 2.82 ± 1.49 b**** 2.87 ± 0.89 b****
ALT (U/L) 26.83 ± 11.44 73.5 ± 16.99a*** 38.5 ± 14.27b** 44.33 ± 15.93b* 50.33 ± 17.44
AST (U/L) 92.17 ± 31.64 288.3 ± 147.7a** 137.7 ± 15.81b* 147 ± 32.83b* 183.2 ± 79.05
ALP (U/L) 187.2 ± 25.86 286.5 ± 53.07a*** 164.2 ± 19.59b**** 166.5 ± 18.41b**** 189 ± 27.41b***
LDH (U/L) 762 ± 63.68 3046 ± 768.1a**** 1577 ± 338.4b*** 1640 ± 693.3b*** 2155 ± 261.2b*
TSP (g/L) 66 ± 8.37 75.5 ± 0.84a** 76 ± 1.67 70 ± 2.76 63.5 ± 2.51b***
  1. Results are expressed as mean ± SD (n = 6)
  2. NC control, T Toxic, Mel15 Melittin15μg, Mel30 Melittin30μg, NR Normal recovery
  3. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001
  4. a: significant Vs NC group, b: significant Vs T group