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Table 2 Biochemical parameters of male rats receiving melittin post isoniazid and rifampicin-induced hepatotoxicity

From: Hepatoprotective activity of melittin on isoniazid- and rifampicin-induced liver injuries in male albino rats

 

NC

T

Mel15

Mel30

NR

DB (ÎĽmol/l)

1.0 ± 0.451

7.05 ± 1.84a****

1.0 ± 0.38b****

1.0 ± 0.27 b****

1.0 ± 0.31b****

TB (ÎĽmol/l)

1.6 ± 0.94

10.45 ± 2.13a****

2 ± 1.05b****

2.82 ± 1.49 b****

2.87 ± 0.89 b****

ALT (U/L)

26.83 ± 11.44

73.5 ± 16.99a***

38.5 ± 14.27b**

44.33 ± 15.93b*

50.33 ± 17.44

AST (U/L)

92.17 ± 31.64

288.3 ± 147.7a**

137.7 ± 15.81b*

147 ± 32.83b*

183.2 ± 79.05

ALP (U/L)

187.2 ± 25.86

286.5 ± 53.07a***

164.2 ± 19.59b****

166.5 ± 18.41b****

189 ± 27.41b***

LDH (U/L)

762 ± 63.68

3046 ± 768.1a****

1577 ± 338.4b***

1640 ± 693.3b***

2155 ± 261.2b*

TSP (g/L)

66 ± 8.37

75.5 ± 0.84a**

76 ± 1.67

70 ± 2.76

63.5 ± 2.51b***

  1. Results are expressed as mean ± SD (n = 6)
  2. NC control, T Toxic, Mel15 Melittin15ÎĽg, Mel30 Melittin30ÎĽg, NR Normal recovery
  3. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001
  4. a: significant Vs NC group, b: significant Vs T group