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Table 3 Esculetin effect on myocardial tissue antioxidant enzyme’s activity in ISO induced myocardial toxicity

From: Exploring cardioprotective potential of esculetin against isoproterenol induced myocardial toxicity in rats: in vivo and in vitro evidence

  SOD(U/mg Protein) CATALASE (μM H202Consumed/mg Protein GSH (μg of GSH/mg Protein) LPO (nm of MDA/mg Protein)
Normal 9.248 ± 1.047 7.965 ± 1.217 11.65 ± 1.108 1.693 ± 0.200
Disease Control 1.646 ± 0.516# 1.159 ± 0.386# 4.027 ± 0.784# 3.313 ± 0.407#
Esculetin(10 mg/kg) 5.804 ± 0.267* 6.484 ± 1.145* 7.766 ± 0.384* 2.044 ± 0.255*
Esculetin(20 mg/kg) 7.241 ± 1.070* 9.249 ± 1.856* 9.719 ± 0.332* 1.661 ± 0.365*
  1. All values are shown as mean ± SEM and n = 6. Data analysis done by one way analysis of variance followed by the Tukey multiple comparison tests. # p < 0.05, indicate disease control compared with normal. ** p < 0.05, indicate Esculetin compared with disease control group