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Table 7 The medians and Weibull parameter of each drug

From: Pharmacovigilance study of anti-infective-related acute kidney injury using the Japanese adverse drug event report database

Classification (ATC code) Administration route Case Median (day) Scale parameter Shape parameter
(po: per os; iv: intravenous injection) (n) (25–75%) α (95% CIa) β (95% CIa)
Total po 756 5.0 (2.0–11.0) 10.60 (9.68–11.59) 0.87 (0.82–0.92)
iv 1800 5.0 (2.0–9.0) 8.28 (7.88–8.71) 1.03 (0.99–1.06)
Antibacterials
 Combinations of penicillins, incl. Beta-lactamase inhibitors (J01CR) po 9 3.0 (2.5–11.5) 8.00 (1.94–30.36) 0.65 (0.34–1.06)
iv 180 4.0 (2.0–8.0) 7.43 (6.34–8.69) 1.04 (0.93–1.15)
 Second-generation cephalosporins (J01DC) po 8 4.5 (1.5–9.0) 6.95 (3.85–12.12) 1.79 (0.83–3.20)
iv 56 3.0 (1.0–5.8) 5.16 (3.86–6.82) 1.06 (0.85–1.30)
 Third-generation cephalosporins (J01DD) po 93 3.0 (1.0–7.0) 7.06 (5.47–9.06) 0.90 (0.77–1.05)
iv 138 4.0 (2.0–7.0) 7.23 (6.01–8.66) 1.02 (0.89–1.15)
 Fourth-generation cephalosporins (J01DE) po 1
iv 83 5.0 (2.0–11.0) 8.24 (6.73–10.02) 1.19 (0.999–1.40)
 Carbapenems (J01DH) po 0
iv 190 5.0 (2.0–9.0) 8.63 (7.37–10.08) 1.03 (0.92–1.14)
 Combinations of sulfonamides and trimethoprim, incl. Derivatives (J01EE) po 112 8.5 (4.0–21.0) 17.57 (13.98–21.94) 0.89 (0.77–1.01)
iv 14 3.0 (1.8–4.0) 3.65 (2.54–5.15) 1.75 (1.12–2.48)
 Other aminoglycosides (J01GB) po 3
iv 143 7.0 (3.0–11.0) 9.64 (8.35–11.09) 1.27 (1.12–1.43)
 Fluoroquinolones (J01MA) po 232 4.0 (2.0–8.0) 7.62 (6.52–8.89) 0.92 (0.83–1.01)
iv 95 4.0 (2.0–7.0) 7.00 (5.72–8.53) 1.14 (0.97–1.33)
 Glycopeptide antibacterials (J01XA) po 10 7.0 (2.0–10.3) 13.15 (4.90–33.47) 0.79 (0.47–1.18)
iv 353 5.0 (2.0–10.0) 8.69 (7.82–9.63) 1.10 (1.01–1.18)
 Polymyxins (J01XB) po 0
iv 83 3.0 (1.0–6.0) 6.25 (5.07–7.64) 1.26 (1.05–1.49)
 Other antibacterials (J01XX) po 9 10.0 (5.5–12.0) 10.06 (6.65–14.84) 2.07 (1.13–3.27)
iv 39 3.0 (1.0–7.0) 7.75 (4.92–11.98) 0.86 (0.66–1.09)
Antimycotics
 Antibiotics (J02AA) po 3
iv 154 5.0 (2.0–9.3) 9.00 (7.45–10.82) 0.94 (0.83–1.05)
 Triazole derivatives (J02AC) po 88 9.5 (3.0–23.0) 19.11 (14.82–24.44) 0.94 (0.79–1.11)
iv 59 5.0 (2.0–18.0) 13.06 (9.27–18.17) 0.83 (0.68–1.01)
 Other antimycotics for systemic use (J02AX) po 2
iv 82 5.0 (3.0–11.0) 10.84 (8.42–13.86) 0.96 (0.81–1.12)
  1. a Confidence Interval