Table 13 Effect of berberine hydrochloride on organ indexes in ICR mice by mKM
Dosage (mg/kg) | Heart (%) | Liver (%) | Spleen (%) | Lung (%) | Kidney (%) |
|---|---|---|---|---|---|
0 | 0.466 ± 0.002 | 4.800 ± 0.373 | 0.387 ± 0.079 | 0.588 ± 0.057 | 1.282 ± 0.140 |
703 | 0.463 ± 0.018 | 5.010 ± 0.558 | 0.406 ± 0.092 | 0.553 ± 0.069 | 1.227 ± 0.203 |
1406 | 0.429 ± 0.028 | 4.740 ± 0.295 | 0.422 ± 0.063 | 0.645 ± 0.097 | 1.162 ± 0.100 |
2812 | 0.454 ± 0.017 | 4.453 ± 0.242 | 0.398 ± 0.075 | 0.667 ± 0.031 | 1.198 ± 0.131 |
5628 | 0.473 ± 0.046 | 4.575 ± 0.173 | 0.394 ± 0.042 | 0.625 ± 0.024 | 1.320 ± 0.073 |
11,250 | 0.442 ± 0.053 | 5.877 ± 0.309** | 0.288 ± 0.065** | 0.697 ± 0.090** | 1.249 ± 0.110 |