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Table 13 Effect of berberine hydrochloride on organ indexes in ICR mice by mKM

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Dosage (mg/kg) Heart (%) Liver (%) Spleen (%) Lung (%) Kidney (%)
0 0.466 ± 0.002 4.800 ± 0.373 0.387 ± 0.079 0.588 ± 0.057 1.282 ± 0.140
703 0.463 ± 0.018 5.010 ± 0.558 0.406 ± 0.092 0.553 ± 0.069 1.227 ± 0.203
1406 0.429 ± 0.028 4.740 ± 0.295 0.422 ± 0.063 0.645 ± 0.097 1.162 ± 0.100
2812 0.454 ± 0.017 4.453 ± 0.242 0.398 ± 0.075 0.667 ± 0.031 1.198 ± 0.131
5628 0.473 ± 0.046 4.575 ± 0.173 0.394 ± 0.042 0.625 ± 0.024 1.320 ± 0.073
11,250 0.442 ± 0.053 5.877 ± 0.309** 0.288 ± 0.065** 0.697 ± 0.090** 1.249 ± 0.110
  1. Note: *P < 0.05 vs Normal, **P < 0.01 vs Normal