Table 6 Lethality and signs of toxicity of mice administrated with berberine hydrochloride by iUDP
Seq. | Dosage (mg/kg) | Δm (g) | Short-term outcome | Symptoms | Pathology |
|---|---|---|---|---|---|
1 | 790 | 1.1 | O | Reduced activity, recovered after 2 h | No visible alterations were found in organs and tissues |
2 | 2500 | 1.5 | O | Reduced activity, recovered after 4.5 h | No visible alterations were found in organs and tissues |
3 | 5000 | 1.4 | X | Reduced activity, weakness, dead after 10 h | Liver was congested |
4 | 2500 | 0.9 | O | Reduced activity, recovered after 4.5 h | No visible alterations were found in organs and tissues |
5 | 5000 | 1.1 | X | Reduced activity, weakness, dead after 8 h | Liver was congested |
6 | 2500 | 1.7 | X | Reduced activity, dead after 16 h | No visible alterations were found in organs and tissues |
7 | 790 | 1.4 | O | Reduced activity, recovered after 1 h | No visible alterations were found in organs and tissues |
8 | 2500 | 1.1 | O | Reduced activity, recovered after 4 h | No visible alterations were found in organs and tissues |
9 | 5000 | 1.0 | X | Reduced activity, weakness, and dead after 18 h | Liver was congested |
Stop criteria met: 3 reversals in 5 tests | |||||