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Table 7 Effect of berberine hydrochloride on organ indexes in ICR mice by iUDP

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Dosage (mg/kg) Heart (%) Liver (%) Spleen (%) Lung (%) Kidney (%)
0 0.466 ± 0.002 4.800 ± 0.373 0.387 ± 0.079 0.588 ± 0.057 1.282 ± 0.140
790 0.472 ± 0.028 4.602 ± 0.295 0.363 ± 0.063 0.580 ± 0.097 1.100 ± 0.100
2500 0.449 ± 0.045 4.472 ± 0.207 0.427 ± 0.096 0.627 ± 0.108 1.280 ± 0.073
5000 0.465 ± 0.039 4. 503 ± 0.200 0.426 ± 0.041* 0.598 ± 0.049 1.129 ± 0.068
  1. Note: *P < 0.05 vs Normal, **P < 0.01 vs Normal