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Table 1 Haematology parameters of rats sacrificed on day 28 of 28-day feeding test (Mean ± SD)

From: Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate

Parameters 0 mg/kg b. w. 50 mg/kg b. w. 100 mg/kg b. w. 300 mg/kg b. w.
Female
 WBC 5.47 ± 1.11 4.94 ± 1.33 4.16 ± 1.08 4.83 ± 1.48
 RBC 8.33 ± 0.98 6.82 ± 1.01* 7.85 ± 0.50 7.50 ± 0.53
 HGB 141.42 ± 8.77 131.37 ± 7.91 135.16 ± 5.94 139.01 ± 7.24
 HCT 40.96 ± 1.66 43.88 ± 2.51 41.24 ± 1.61 44.01 ± 1.87*
 MCV 57.21 ± 1.32 58.56 ± 1.08 56.73 ± 1.43 56.84 ± 1.22
 MCH 21.60 ± 0.79 22.07 ± 0.95 20.81 ± 0.98 21.13 ± 0.88
 MCHC 357.47 ± 12.04 360.10 ± 10.35 348.17 ± 19.45 350.26 ± 13.55
 PLT 1011.28 ± 124.25 911.31 ± 118.19 1180.69 ± 158.54 915.68 ± 135.97
Male
 WBC 7.34 ± 1.56 8.21 ± 1.73 6.90 ± 2.11 7.67 ± 1.26
 RBC 8.37 ± 0.67 8.48 ± 0.88 7.88 ± 0.72 8.73 ± 0.90
 HGB 145.84 ± 7.90 139.36 ± 8.40 138.26 ± 6.99 143.52 ± 9.31
 HCT 40.72 ± 1.37 40.22 ± 1.83 41.91 ± 1.60 39.86 ± 2.51
 MCV 57.75 ± 1.30 55.98 ± 0.98* 58.24 ± 1.31 59.03 ± 1.04
 MCH 21.67 ± 0.87 20.89 ± 0.93 21.32 ± 0.75 21.56 ± 0.87
 MCHC 341.83 ± 15.83 352.21 ± 21.01 354.37 ± 11.90 360.81 ± 19.39
 PLT 952.67 ± 142.45 893.28 ± 107.30 995.37 ± 135.60 979.47 ± 150.94
  1. Abbreviations: WBC white blood cells (109/L), RBC red blood cells (1012/L), HGB hemoglobin (g/L), HCT hematocrit (%), MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, PLT platelets (103/μL). Values represent means ± SD. *p < 0.05 vs. control group (0 mg/kg b. w.)