Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate

Table 1 Haematology parameters of rats sacrificed on day 28 of 28-day feeding test (Mean ± SD)

Parameters	0 mg/kg b. w.	50 mg/kg b. w.	100 mg/kg b. w.	300 mg/kg b. w.
Female
WBC	5.47 ± 1.11	4.94 ± 1.33	4.16 ± 1.08	4.83 ± 1.48
RBC	8.33 ± 0.98	6.82 ± 1.01*	7.85 ± 0.50	7.50 ± 0.53
HGB	141.42 ± 8.77	131.37 ± 7.91	135.16 ± 5.94	139.01 ± 7.24
HCT	40.96 ± 1.66	43.88 ± 2.51	41.24 ± 1.61	44.01 ± 1.87*
MCV	57.21 ± 1.32	58.56 ± 1.08	56.73 ± 1.43	56.84 ± 1.22
MCH	21.60 ± 0.79	22.07 ± 0.95	20.81 ± 0.98	21.13 ± 0.88
MCHC	357.47 ± 12.04	360.10 ± 10.35	348.17 ± 19.45	350.26 ± 13.55
PLT	1011.28 ± 124.25	911.31 ± 118.19	1180.69 ± 158.54	915.68 ± 135.97
Male
WBC	7.34 ± 1.56	8.21 ± 1.73	6.90 ± 2.11	7.67 ± 1.26
RBC	8.37 ± 0.67	8.48 ± 0.88	7.88 ± 0.72	8.73 ± 0.90
HGB	145.84 ± 7.90	139.36 ± 8.40	138.26 ± 6.99	143.52 ± 9.31
HCT	40.72 ± 1.37	40.22 ± 1.83	41.91 ± 1.60	39.86 ± 2.51
MCV	57.75 ± 1.30	55.98 ± 0.98*	58.24 ± 1.31	59.03 ± 1.04
MCH	21.67 ± 0.87	20.89 ± 0.93	21.32 ± 0.75	21.56 ± 0.87
MCHC	341.83 ± 15.83	352.21 ± 21.01	354.37 ± 11.90	360.81 ± 19.39
PLT	952.67 ± 142.45	893.28 ± 107.30	995.37 ± 135.60	979.47 ± 150.94

Abbreviations: WBC white blood cells (10⁹/L), RBC red blood cells (10¹²/L), HGB hemoglobin (g/L), HCT hematocrit (%), MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, PLT platelets (10³/μL). Values represent means ± SD. *p < 0.05 vs. control group (0 mg/kg b. w.)

ISSN: 2050-6511