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Table 2 Biochemical parameters of rats sacrificed on day 28 of 28-day feeding test (Mean ± SD)

From: Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate

Parameters

0 mg/kg b. w.

50 mg/kg b. w.

100 mg/kg b. w.

300 mg/kg b. w.

Female

 ALT (U/L)

44.01 ± 5.89

45.64 ± 6.73

59.08 ± 6.99**

51.78 ± 4.82*

 ALP (U/L)

243.86 ± 36.02

196.54 ± 42.84

220.15 ± 45.12

198.22 ± 36.86

 AST (U/L)

117.47 ± 23.55

108.93 ± 26.11

122.98 ± 24.20

118.80 ± 23.07

 TB (μmol/L)

2.91 ± 0.40

2.25 ± 0. 37*

3.08 ± 0.43

2.34 ± 0.47

 TC (mmol/L)

1.54 ± 0.23

1.57 ± 0.19

1.70 ± 0.18

1.41 ± 0.15

 HDL (mmol/L)

0.47 ± 0.05

0.54 ± 0.06

0.57 ± 0.08*

0.45 ± 0.07

 LDL (mmol/L)

0.78 ± 0.08

0.80 ± 0.06

0.86 ± 0.06

0.79 ± 0.06

 TG (mmol/L)

0.67 ± 0.34

0.74 ± 0.40

0.82 ± 0.39

0.71 ± 0.27

 Crea (μmol/L)

39.65 ± 6.73

38.08 ± 5.78

36.76 ± 6.78

40.29 ± 6.26

 UN (mmol/L)

6.97 ± 0.67

7.09 ± 0.77

5.89 ± 0.68*

6.74 ± 0.47

 TP (g/L)

64.77 ± 4.99

60.92 ± 5.38

65.69 ± 5.50

58.89 ± 4.69

 Alb (g/L)

31.33 ± 3.39

31.17 ± 3.03

30.28 ± 4.53

30.03 ± 3.68

 Glu (mmol/L)

5.62 ± 0.68

6.18 ± 0.50

6.15 ± 0.45

5.59 ± 0.59

 Ca (mmol/L)

2.64 ± 0.50

2.39 ± 0.38

2.56 ± 0.52

2.38 ± 0.46

 P (mmol/L)

3.00 ± 0.25

2.64 ± 0.31

2.79 ± 0.30

2.92 ± 0.27

Male

 ALT (U/L)

52.45 ± 5.76

60.28 ± 6.72

47.93 ± 5.46

51.42 ± 6.49

 ALP (U/L)

246.66 ± 42.88

257.62 ± 37.88

283.76 ± 46.69*

222.44 ± 40.11

 AST (U/L)

110.45 ± 24.35

116.05 ± 20.23

125.27 ± 26.17

93.63 ± 24.24

 TB (μmol/L)

2.64 ± 0.37

2.93 ± 0.54

2.64 ± 0.41

2.10 ± 0.46

 TC (mmol/L)

1.54 ± 0.16

1.55 ± 0.17

1.61 ± 0.21

1.44 ± 0.23

 HDL (mmol/L)

0.52 ± 0.08

0.50 ± 0.05

0.57 ± 0.09

0.54 ± 0.08

 LDL (mmol/L)

0.85 ± 0.08

0.88 ± 0.06

0.85 ± 0.04

0.80 ± 0.07

 TG (mmol/L)

0.69 ± 0.38

0.75 ± 0.40

0.86 ± 0.33

0.59 ± 0.30

 Crea (μmol/L)

36.00 ± 4.61

42.27 ± 6.47

35.52 ± 5.65

30.79 ± 6.13

 UN (mmol/L)

5.42 ± 0.43

5.16 ± 0.49

6.13 ± 0.76

5.08 ± 0.56

 TP (g/L)

62.83 ± 4.85

69.64 ± 5.80

68.36 ± 4.76

64.29 ± 4.33

 Alb (g/L)

30.20 ± 4.02

31.18 ± 4.08

30.90 ± 3.55

28.49 ± 3.15

 Glu (mmol/L)

4.24 ± 0.55

4.92 ± 0.56

4.04 ± 0.49

3.83 ± 0.52

 Ca (mmol/L)

2.34 ± 0.38

2.53 ± 0.51

2.50 ± 0.45

1.97 ± 0.38

 P (mmol/L)

2.83 ± 0.21

2.68 ± 0.27

3.05 ± 0.25

2.44 ± 0.27*

  1. Abbreviations: ALT Alanine transaminase, ALP Alkaline phosphatase, AST Aspartate transaminase, TB Total bilirubin, TC Total cholesterol, HDL High density lipoprotein, LDL low density lipoprotein, TG triglycerides, Crea Creatinine, UN Urea nitrogen, TP Total protein, Alb Albumin, Glu Glucose, Ca Calcium, P phosphorous. Values represent means ± SD. *p < 0.05, **p < 0.01 vs. control group (0 mg/kg b. w.)
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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