Table 4 Absolute and relative organ weights from male rats treated orally with Py-mulin for 28 days
From: Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate
Parameters | 0 mg/kg b.w. | 50 mg/kg b.w. | 100 mg/kg b.w. | 300 mg/kg b.w. |
|---|---|---|---|---|
Absolute organ weight (g) | ||||
Heart | 0.94 ± 0.0.09 | 0.93 ± 0.08 | 0.88 ± 0.13 | 0.97 ± 0.12 |
Liver | 9.82 ± 0.76 | 9.55 ± 0.53 | 9.08 ± 0.68 | 9.69 ± 0.40 |
Spleen | 0.58 ± 0.10 | 0.54 ± 0.11 | 0.56 ± 0.08 | 0.52 ± 0.07 |
Lungs | 1.31 ± 0.21 | 1.25 ± 0.16 | 1.10 ± 0.12 | 1.17 ± 0.13 |
Kidneys | 1.89 ± 0.22 | 1.82 ± 0.17 | 1.75 ± 0.19 | 1.85 ± 0.28 |
Thymus | 0.44 ± 0.07 | 0.45 ± 0.12 | 0.34 ± 0.06* | 0.47 ± 0.11 |
Testis | 2.69 ± 0.22 | 2.68 ± 0.18 | 2.67 ± 0.18 | 2.72 ± 0.23 |
relative organ weight | ||||
Heart | 0.37 ± 0.03 | 0.38 ± 0.03 | 0.38 ± 0.04 | 0.40 ± 0.04 |
Liver | 3.88 ± 0.24 | 3.91 ± 0.12 | 3.90 ± 0.14 | 4.04 ± 0.12 |
Spleen | 0.23 ± 0.03 | 0.22 ± 0.04 | 0.24 ± 0.03 | 0.22 ± 0.02 |
Lungs | 0.52 ± 0.06 | 0.51 ± 0.06 | 0.47 ± 0.03 | 0.493 ± 0.04 |
Kidneys | 0.74 ± 0.06 | 0.75 ± 0.04 | 0.75 ± 0.08 | 0.77 ± 0.09 |
Thymus | 0.17 ± 0.02 | 0.18 ± 0.04 | 0.15 ± 0.03 | 0.19 ± 0.04 |
Testis | 1.06 ± 0.05 | 1.10 ± 0.07 | 1.15 ± 0.06* | 1.13 ± 0.06 |