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Table 4 Absolute and relative organ weights from male rats treated orally with Py-mulin for 28 days

From: Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate

Parameters 0 mg/kg b.w. 50 mg/kg b.w. 100 mg/kg b.w. 300 mg/kg b.w.
Absolute organ weight (g)
 Heart 0.94 ± 0.0.09 0.93 ± 0.08 0.88 ± 0.13 0.97 ± 0.12
 Liver 9.82 ± 0.76 9.55 ± 0.53 9.08 ± 0.68 9.69 ± 0.40
 Spleen 0.58 ± 0.10 0.54 ± 0.11 0.56 ± 0.08 0.52 ± 0.07
 Lungs 1.31 ± 0.21 1.25 ± 0.16 1.10 ± 0.12 1.17 ± 0.13
 Kidneys 1.89 ± 0.22 1.82 ± 0.17 1.75 ± 0.19 1.85 ± 0.28
 Thymus 0.44 ± 0.07 0.45 ± 0.12 0.34 ± 0.06* 0.47 ± 0.11
 Testis 2.69 ± 0.22 2.68 ± 0.18 2.67 ± 0.18 2.72 ± 0.23
relative organ weight
 Heart 0.37 ± 0.03 0.38 ± 0.03 0.38 ± 0.04 0.40 ± 0.04
 Liver 3.88 ± 0.24 3.91 ± 0.12 3.90 ± 0.14 4.04 ± 0.12
 Spleen 0.23 ± 0.03 0.22 ± 0.04 0.24 ± 0.03 0.22 ± 0.02
 Lungs 0.52 ± 0.06 0.51 ± 0.06 0.47 ± 0.03 0.493 ± 0.04
 Kidneys 0.74 ± 0.06 0.75 ± 0.04 0.75 ± 0.08 0.77 ± 0.09
 Thymus 0.17 ± 0.02 0.18 ± 0.04 0.15 ± 0.03 0.19 ± 0.04
 Testis 1.06 ± 0.05 1.10 ± 0.07 1.15 ± 0.06* 1.13 ± 0.06
  1. Values are mean ± SD for 10 rats in each group
  2. *Statistically significant difference compared to control (p < 0.05)