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Fig. 5 | BMC Pharmacology and Toxicology

Fig. 5

From: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

Fig. 5

A photomicrograph of the cross sections of the liver in (A) group Ӏ and (B) group ӀӀ showing PAS positive granules (arrows) within the cytoplasm of the hepatcoytes (C) group ӀӀӀ showing weaker positive PAS reaction as compared to the group Ӏ (D) group Ӏ showing the normal distribution of collagen fibers (arrow) around the central vein (CV) (E) group ӀӀ showing collagen fibers proliferation (arrow) around congested central vein (CV) and hemorrhage (arrow head) in between the hepatocytes and inside the central vein (F) group ӀӀӀ showing the collagen fibers deposition (arrow), hemorrhage (arrow head) in between the hepatocytes and destructed central vein (CV) congested with the red blood cells (arrow head. (A-C: PAS × 400, d-f: Masson’s trichrome × 400, Scale bar = 20 μm)

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