Table 4 Probabilities of digoxin concentration reaching intoxication risk ranges according to renal function and the use of amiodarone
Daily maintenance dose of digoxin, mg | CLCR, mL/min | No amiodarone | Amiodarone | ||
|---|---|---|---|---|---|
≥0.9 ng/mL | ≥1.2 ng/mL | ≥0.9 ng/mL | ≥1.2 ng/mL | ||
0.25 | 90 | 61.9 | 43.0 | 79.0 | 65.7 |
0.25 | 60 | 72.7 | 55.7 | 86.4 | 74.5 |
0.25 | 30 | 86.9 | 76.3 | 95.0 | 88.1 |
0.125 | 90 | 18.7 | 7.0 | 37.1 | 19.0 |
0.125 | 60 | 28.1 | 12.4 | 51.6 | 31.5 |
0.125 | 30 | 51.3 | 31.1 | 71.4 | 54.4 |
0.0625 | 90 | 0.9 | 0.0 | 3.7 | 0.7 |
0.0625 | 60 | 1.8 | 0.5 | 8.2 | 1.7 |
0.0625 | 30 | 11.2 | 3.1 | 24.3 | 10.6 |