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Fig. 2 | BMC Pharmacology and Toxicology

Fig. 2

From: Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway

Fig. 2

DEX pretreatment reduces the propofol-induced neuronal injury in mouse hippocampus. A hippocampal neuronal apoptosis in mouse brains measured with TUNEL staining; B Arc positive expression detected with immunohistochemistry in rat hippocampus; C miR-377-5p expression and Arc mRNA expression quantified using PR-qPCR; D protein levels of DNMT3A, DNMT3B, and Arc measured using western blot analysis, and the full-length blots/gels are presented in Figure S2. Each value represents the mean ± SD for n = 3. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. DEX, dexmedetomidine; TUNEL, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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