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Table 6 Patient-related factors associated with ADE occurrence in the medical ward of WSUTRH, February 2021 to July 2021

From: Incidence of adverse drug events in patients hospitalized in the medical wards of a teaching referral hospital in Ethiopia: a prospective observational study

Disease and drug related variables

COR (95% CI)

P value

AOR (95% CI)

P value

Age (year), mean ± SD 44 (±18)

1.017 (1.000–1.035)

0.041

1.006 (0.980–1.032)

0.638

Educational status

No formal education

0.873 (0.248–3.065)

0.832

0.618 (0.115–3.305)

0.574

Primary

0.267 (0.076–0 .933)

0.039

0.266 (0.053–1.338)

0.108

Secondary

0.589 (0.397–0.173)

0.397

0.939 (0.188–4.676)

0.939

Tertiary

1

   

Hospitalization during the 3 months before the study period

No

1

   

yes

3.086 (1.472–6.466)

0.003

3.200 (0.927–11.047)

0.066

Previous diagnosis of infectious diseases

No

1

   

yes

2.003 (0.979–4.097)

0.057

1.639(.562–4.779)

0.366

Previous diagnosis of circulatory system diseases

No

1

   

yes

2.34 (1.080–5.066)

0.031

1.612 (0.507–5.126)

0.418

Diagnosis of blood and immune diseases during the study period

No

1

   

yes

1.837 (1.012–3.334)

0.046

3.925 (1.709–9.013)

0.001

Diagnosis of nervous system diseases during the study period

No

1

   

yes

2.951 (1.202–7.247)

0.018

1.649(.407–6.669)

0.483

CCI score

1.198 (1.033–1.389)

0.017

1.250 (0.961–1.624)

0.095

LOHS (days)

1.073 (1.028–1.119)

0.001

1.066 (1.009–1.125)

0.021

Previous medication prescription history

No

1

   

yes

2.075 (1.136–3.791)

0.018

1.054 (0.349–3.185)

0.925

Cardiovascular medicine prescription history

No

1

   

yes

2.201 (1.657–7.897)

0.001

2.040 (0.392–10.599)

0.396

Antibiotics prescription history

No

1

   

yes

1.675 (0.875–3.207)

0.119

1.894 (0.654–5.481)

0.239

Being on medication at admission

No

1

   

yes

2.689 (1.437–5.035)

0.002

0.891 (0.218–3.635)

0.873

Antibiotics prescription during the study period

No

1

   

yes

1.566 (0.818–2.998)

0.176

1.057 (0.449–2.483)

0.899

Cardiovascular medicines during the study period

No

1

   

yes

2.632 (1.199–5.776)

0.016

3.368 (1.137–9.979)

0.028

Antiepileptic prescription during the study period

No

1

   

yes

6.502 (2.083–20.291)

0.001

5.44 (0.962–30.745)

0.055

Analgesic agents’ prescription during the study period

No

1

   

yes

3.339 (0.931–11.976)

0.064

0.739 (0.110–4.951)

0.755

Gastrointestinal medicines prescription during the study period

No

1

   

yes

1.588 (0.863–2.923)

0.137

0.774 (0.335–1.786)

0.548

Number of medications prescribed during the hospital stay

1.409 (1.198–1.657)

< 0.001

1.310 (1.041–1.647)

0.021

  1. AOR,Adjusted odds ratio, CCI Charlson’s comorbidity index, COR Crude odds ratio, LOHS Length of hospital stay