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Table 1 Baseline characteristics of 346 T2DM patients treated with acarbose

From: Predictors of acarbose therapeutic efficacy in newly diagnosed type 2 diabetes mellitus patients in China

Variables

Values

Sex (male/female)

210/136

Age (years)

50.4 ± 9.2

Disease duration (months)

1.5 (1.1–2.8)

Weight (kg)

70.0 ± 10.6

BMI (kg/m2)

25.5 ± 2.7

SBP (mmHg)

124.1 ± 12.5

DBP (mmHg)

79.5 ± 8.8

HbA1c (%)

7.5 ± 1.2

FPG (mmol/L)

8.2 ± 1.5

2 h PG (mmol/L)

12.5 ± 2.8

FINS (mU/L)

12.6 ± 9.1

2 h INS (mU/L)

34.1 ± 18.6

IGI

2.6 (1.2–4.7)

HOMA-IR

3.7 (2.4–5.9)

HOMA-B

48.2 (28.8–75.7)

AUCglucagon (pg/mL*min)

12,127 (9673–15,970)

AUCinsulin (uIU/mL*min)

4421 (3142–6240)

AUCGLP- 1 (pmol*min)

2743 (1725–4320)

  1. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, HbA1c Glycated hemoglobin, FPG fasting plasma glucose, 2 h PG 2-hour postprandial blood glucose, FINS Fasting insulin, 2 h INS 2-hour postprandial insulin, IGI Early insulin secretion index, HOMA-IR homeostasis model assessment of insulin resistance index, HOMA-B homeostasis model assessment of beta cell function, GLP- 1 Glucagon-like peptide- 1, AUC Area under the curve. AUC (insulin, glucagon, and GLP- 1) was calculated by trapezoid method from the four-point curve as 0 min, 30 min, 120 min, and 180 min. AUC was calculated with the following equations (for example): AUCinsulin = (INS0min + INS 30 min) × 30/2 + (INS30 min + INS120 min) × 90/2 + (INS120 min + INS180 min) × 60/2. HOMA index was calculated with the following formulae: HOMA-IR = FINS×FPG/22.5; HOMA-B = 20 × FINS/(FPG-3.5); IGI = (INS30-FINS)/(PG30-FPG) [6]
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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