Table 4 Characteristics of the studies included in the systematic review about Cmin (children)
Study | Design of study | Country of study | Duration of therapy (days) | Age of children | No. of children | Cmin (μg/ml) of children | |
|---|---|---|---|---|---|---|---|
Thrombocytopenia | Non-thrombocytopenia | ||||||
Cojutti 2015 [57] | Retrospective study | Italy | Group1 Median: 15.7 Group2 Median: 11 | Group1 Mean: 4.9 ± 2.8 Group2 Mean: 14.9 ± 1.3 | 23 (8/15) | Median: 7.17 | ― |
Kosaka 2009 [43] | Prospective study | Japan | Mean: 47.5 ± 48.4 | Mean: 1.2 ± 0.8 | 4 (0/4) | ― | 0.1, 1.9, 2.7, 3.5, 4.1a |
Matsumoto 2014 [44] | Prospective observational study | Japan | Mean: 17.8 ± 7.0 | Mean: 6.4 ± 3.2 | 5 (1/4) | 4.7b | 1.4, 1.8, 4.4, 4.6 |