Fig. 2

Photomicrographs of cortical brain sections of WIN55, 212–2 treated mice versus controls. Image a: control and vehicle groups showing rounded non pyramidal granule cells (G) with open face nuclei and large sized pyramidal cells (arrow) with triangular shaped cell bodies, basophilic cytoplasm, rounded nuclei, and long apical dendrites. The ground substance between the nerve cells was normally occupied with homogenous eosinophilic neuropil (N). Image b: the low dose groups showing some pyramidal cells are deformed with deeply stained nuclei and surrounded by haloes (arrow), granule cells (G) with dark smaller nuclei surrounded by halo (H) nuclei and neuropil (N) in between cells. Image c: the high dose groups show more deformed and shrinked pyramidal cells (arrow), granule cells (G) with dark smaller nuclei surrounded by halo (H) nuclei and neuropil (N) in between cells. Stain H&E (scale bar = 100um)