Fig. 1

Mean (mean ± SD) plasma concentration vs. time profiles of oseltamivir and oseltamivir carboxylic under fasting conditions (pharmacokinetic concentration sets). a Mean (mean ± SD) plasma concentration–time profiles of oseltamivir after oral administration of test product (T) and reference product (R) in 40 subjects. b Mean (mean ± SD) plasma concentration–time profiles of oseltamivir carboxylic after oral administration of test product (T) and reference product (R) in 40 subjects. Subjects in the RT sequence group S048 (K018) were excluded from the pharmacokinetic analysis due to the occurrence of vomiting within twice the median time of T_max after administration of the first cycle, and none of the oseltamivir concentration data for that cycle