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Fig.1 | BMC Pharmacology and Toxicology

Fig.1

From: Thiram, an inhibitor of 11ß-hydroxysteroid dehydrogenase type 2, enhances the inhibitory effects of hydrocortisone in the treatment of osteosarcoma through Wnt/β-catenin pathway

Fig.1

Effects of HC and thiram on osteosarcoma in vitro and in mice. A The molecular structure of thiram. B Effect of thiram on normal human osteocytes and human osteosarcoma cells. C Effect of thiram on normal mouse osteocytes and mouse osteosarcoma cells. D The combination of HC and thiram inhibited the proliferation of osteosarcoma cells more than HC alone. The red * is the comparison of HC and HC combined with thiram. The black * is the comparison between the HC and control groups. E The obtained tumor tissues in each group (the tumors of one mouse in the HC treatment group and two mice in the HC combined with thiram group kept decreasing and then disappeared during drug treatment, so their tumors could not be collected). F The tumor shrinkage after drug treatment. B-D Data are presented as the mean ± SE (n = 3). * p < 0.05,** p < 0.01,*** p < 0.001

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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