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Fig. 4 | BMC Pharmacology and Toxicology

Fig. 4

From: Vanillic acid alleviates methamphetamine-induced mitochondrial toxicity in cardiac mitochondria via antioxidant activity and inhibition of MPT Pore opening: an in-vitro study

Fig. 4

Protective effect of VA on GSH depletion caused by methamphetamine. Cardiac mitochondria were treated/cotreated with methamphetamine, methamphetamine plus various concentrations (10, 50 and 100 µM) of VA and VA (100 µM) alone for 60 min. The level of GSH was measured by the protocol of Ellman, as previously described in material and methods. Methamphetamine decreased GSH amounts in cardiac mitochondria. Treatment with various concentrations (50 and 100 µM) significantly inhibit the GSH depletion induced by methamphetamine. Data are presented as the mean ± SD. *** p < 0.001 versus untreated control; ### p < 0.001 versus methamphetamine group (one-way ANOVA followed by Tukey’s multiple comparison tests). GSH, glutathione; METH, methamphetamine; VA, Vanillic acid; SD standard deviation

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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