Table 3 PK parameters from the three-compartmental model

Clearance, CL (L/h)

358.3

Central compartment volume, Vc (L)

16.02

Elimination half-life, T_1/2 (h)

18.82

Distribution rate constant from C1 to C2, K12 (h^− 1)

1.2677

Distribution rate constant from C2 to C1, K21 (h^− 1)

0.65964

Distribution rate constant from C1 to C3, K13 (h^− 1)

0.07081

Distribution rate constant from C3 to C1, K31 (h^− 1)

0.04706