Table 4 Simulated and observed pharmacokinetic parameters after oral administration of 20 mg and 40 mg tablets
From: In silico prediction of bioequivalence of atorvastatin tablets based on GastroPlus™ software
Parameters | Atorvastatin 20 mg | Atorvastatin 40 mg | |||||
|---|---|---|---|---|---|---|---|
Obs | Pred | Pred/Obs | Obs | Pred | Pred/Obs | ||
Cmax (µg/L) | 10.81 | 9.44 | 0.87 | 14.06 | 16.75 | 1.19 | |
AUC0–t (µg·h/L) | 53.59 | 52.93 | 0.99 | 61.74 | 94.96 | 1.54 | |
AUC0–∞(µg·h/L) | 55.56 | 55.51 | 1.00 | 61.77 | 99.59 | 1.61 | |