Table 3 Toxicokinetic parameters following iv administration of 600 mg/kg GHB in females over the estrus cycle, ovariectomized females (OVX), males and castrated (CST) males. Data is presented as mean ± SD, N = 4–5. ^*P < 0.05 when compared to proestrus females. ^#P < 0.05 when compared to estrus females

89 ± 16.8

93 ± 18.3

108 ± 16.3

129 ± 16.8

120 ± 35.5

115 ± 21.6

116 ± 17.1

6.8 ± 2.6

6.7 ± 2.5

5.6 ± 2.1

4.7 ± 1.8

5.3 ± 2.1

5.4 ± 2.1

5.3 ± 2.1

3.7 ± 0.4

3.3 ± 0.09

2.6 ± 0.3

1.9 ± 0.7^*#

1.9 ± 1.1^*#

2.0 ± 1.0^*

2.1 ± 0.8^*

0.54 ± 0.03

0.49 ± 0.09

0.47 ± 0.05

0.40 ± 0.07

0.36 ± 0.1^*

0.38 ± 0.06

0.39 ± 0.03

3.1 ± 0.4

3.4 ± 0.7

3.0 ± 0.6

2.9 ± 0.6

3.4 ± 1.1

3.4 ± 1.1

3.2 ± 0.5