Table 4 Toxicokinetic parameters following iv administration of 1000 mg/kg GHB in females over the estrus cycle, ovariectomized females (OVX), males and castrated (CST) males. Data is presented as mean ± SD, N = 3–5. *P < 0.05 when compared to proestrus females. αP < 0.05 when compared to metestrus females. βP < 0.05 when compared to diestrus females
Parameter | Units | Proestrus | Estrus | Metestrus | Diestrus | OVX | Male | CST |
|---|---|---|---|---|---|---|---|---|
AUC | mg*min/mL | 124 ± 12.7 | 154 ± 20.5 | 126 ± 10.8 | 135 ± 11.5 | 196 ± 33.5 | 212 ± 65.2* α | 189 ± 43.1 |
CL | mL/min/kg | 8.1 ± 0.8 | 6.6 ± 0.9 | 8.0 ± 0.7 | 7.4 ± 0.6 | 5.2 ± 0.9*α | 5.1 ± 1.4* α β | 5.6 ± 1.3* α |
CLR | mL/min/kg | 3.7 ± 0.8 | 2.8 ± 0.4 | 3.9 ± 0.4 | 3.8 ± 0.5 | 2.5 ± 0.6 | 2.4 ± 1.2 | 2.8 ± 0.8 |
fe |  | 0.45 ± 0.06 | 0.43 ± 0.03 | 0.49 ± 0.02 | 0.51 ± 0.08 | 0.47 ± 0.07 | 0.45 ± 0.09 | 0.50 ± 0.03 |
CLm | mL/min/kg | 4.3 ± 0.5 | 3.8 ± 0.6 | 4.1 ± 0.3 | 3.6 ± 0.8 | 2.8 ± 0.5* | 2.7 ± 0.5* | 2.7 ± 0.5* |