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Table 1 Physicochemical and pharmacokinetics properties of asiatic acid and asiaticoside A

From: In-silico and in-vitro screening of Asiatic acid and Asiaticoside A against Cathepsin S enzyme

  1. (GI-Gastrointestinal; Pgp- Permeability Glycoprotein; BBB- blood brain barrier; cLogP- partition coefficient; Log S- aqueous solubility; CYP- cytochrome P450 enzyme; TPSA- Topological Polar Surface Area). According to Lipinski rule and other variant, a potential drug for oral administration should have at least 5 Hydrogen bond donors, 10 Hydrogen bond acceptors, molecular weight less than 500, cLogP less than 5, at least 10 rotatable bonds, less than 140Ã…2 surface area [31]
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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