Table 1 Screening of candidate detection genotypes/SNPs
Genotype/SNP | Relationship with ADRs of opioid drugs | PharmGKB evidence level |
|---|---|---|
CYP2D6 (008rs1065852) | The toxicity of codeine is easily increased in the ultrafast metabolic type. Polymorphism at this site may be related to the gastrointestinal system damage, nervous system damage, respiratory system damage and other toxic reactions caused by opioid drugs. | 1A |
CYP3A5*3 (058rs776746) | The toxicity of opiates is easily increased in the ultrafast metabolic type. It may be related to the gastrointestinal system damage, nervous system damage, respiratory system damage and other toxic reactions caused by opioid drugs. | 2A |
ABCB1 (062rs1045642) | The ABCB1 gene encodes the P protein, and opioid drugs are the substrate of P protein; polymorphism is related to the respiratory depression caused by opioid drugs and may also be related to increases in other system damage. | 3 |
OPRM1 (047rs1799971) | Some studies report that polymorphism at this site is related to the gastrointestinal system damage, respiratory system damage and other toxic reactions caused by opioid drugs. | 3 |