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Table 3 Nebulization performance of the five nebulizers with varying IgG concentrations in ISO breathing pattern

From: Evaluation of antibody drug delivery efficiency via nebulizer in various airway models and breathing patterns

IgG conc. (mg/mL)

Nebulizer

Residual volume (%)

Nebulization time (min)

Output rate (mL/min)

1

JN-PARIr

37.7 ± 1.1

5.6 ± 0.1

0.225 ± 0.00

JN-PARIb

30.9 ± 0.6

4.4 ± 0.1

0.315 ± 0.01

SMN-U150

14.1 ± 2.8

5.2 ± 0.7

0.334 ± 0.02

VMN-SM1

9.5 ± 2.3

6.7 ± 0.1

0.269 ± 0.01

VMN-SM3

8.7± 2.0

5.2 ± 0.1

0.351 ± 0.01

10

JN-PARIr

35.4 ± 4.1

5.8 ± 0.8

0.223 ± 0.02

JN-PARIb

35.6 ± 7.0

4.6 ± 0.2

0.282 ± 0.05

SMN-U150

15.7 ± 0.7

5.3 ± 0.2

0.317 ± 0.01

VMN-SM1

13.6 ± 3.0

7.1 ± 0.6

0.246 ± 0.02

VMN-SM3

15.1 ± 2.4

5.4 ± 0.1

0.314 ± 0.01*

20

JN-PARIr

34.6 ± 3.0

6.1 ± 0.9*

0.216 ± 0.02

JN-PARIb

32.2 ± 1.9

4.9 ± 0.8

0.275 ± 0.02

SMN-U150

16.2 ± 2.4

5.8 ± 0.8

0.290 ± 0.01

VMN-SM1

11.6 ± 1.7

7.4 ± 0.2*

0.239 ± 0.00*

VMN-SM3

13.1 ± 0.7

6.3 ± 0.1*

0.275 ± 0.01*

40

JN-PARIr

28.2 ± 4.0

7.2 ± 0.9*

0.202 ± 0.02

JN-PARIb

24.6 ± 1.8

5.9 ± 0.7*

0.258 ± 0.02

SMN-U150

10.4 ± 4.4

6.4 ± 0.7*

0.281 ± 0.03*

VMN-SM1

19.6 ± 1.6*

8.1 ± 0.9*

0.199 ± 0.01*

VMN-SM3

13.7 ± 5.8

7.6 ± 0.7*

0.229 ± 0.01*

  1. All data are presented as the mean ± SD values. * p < 0.05 versus 1 mg/mL of IgG