Table 4 Delivered dose (DD, mg) for adult breathing patterns. The DD values of the five nebulizers for the adult asthma breathing pattern decreased compared to those for the normal adult breathing pattern at all IgG concentrations

ISO 27427

1

0.506 ± 0.04

0.489 ± 0.07

0.436 ± 0.02*

0.539 ± 0.04

0.278 ± 0.02

10

5.250 ± 0.16*

4.795 ± 0.13*

4.386 ± 0.10*

5.433 ± 0.44

2.814 ± 0.12*

20

10.843 ± 0.64*

10.421 ± 0.50*

9.504 ± 0.36*

11.830 ± 0.14*

7.426 ± 0.06*

40

18.049 ± 1.73

19.659 ± 1.57

19.137 ± 1.14

20.248 ± 1.43

12.435 ± 0.18

Normal adult

1

0.498 ± 0.02

0.477 ± 0.02

0.374 ± 0.01

0.579 ± 0.01

0.298 ± 0.03

10

4.831 ± 0.10

4.036 ± 0.08

3.224 ± 0.15

5.277 ± 0.20

2.538 ± 0.13

20

8.021 ± 0.09

7.234 ± 0.24

6.684 ± 0.23

8.714 ± 0.11

5.647 ± 0.18

40

17.281 ± 0.39

12.639 ± 0.28

13.972 ± 0.50

18.136 ± 0.81

10.651 ± 0.35

Asthma adult

1

0.355 ± 0.02*

0.336 ± 0.02*

0.305 ± 0.02*

0.472 ± 0.02*

0.239 ± 0.01*

10

2.889 ± 0.04*

2.645 ± 0.18*

2.404 ± 0.11*

3.107 ± 0.05*

1.797 ± 0.08*

20

6.443 ± 0.51*

6.048 ± 0.46*

4.797 ± 0.18*

7.467 ± 0.11*

4.392 ± 0.13*

40

11.910 ± 0.41*

10.349 ± 0.65*

9.318 ± 0.26*

12.566 ± 0.22*

6.821 ± 0.57*