Table 5 Delivered dose (DD, mg)/Loading dose (LD, mg) for adult breathing patterns. The DD/LD (%) values of the five nebulizers for the asthma adult breathing pattern decreased compared to those for the normal adult breathing pattern at all IgG concentrations

ISO 27427

1

25.21 ± 1.75

24.31 ± 3.23

21.69 ± 1.05*

26.90 ± 1.82

0.278 ± 0.80

10

26.11 ± 0.78*

23.89 ± 0.64*

21.92 ± 0.50*

27.11 ± 2.28

2.814 ± 0.63*

20

26.96 ± 1.52*

25.99 ± 1.28*

23.64 ± 0.99*

29.47 ± 0.45*

7.426 ± 0.14*

40

22.40 ± 2.19

24.33 ± 1.98*

23.85 ± 1.44*

25.25 ± 1.85

12.435 ± 0.24*

Normal adult

1

24.83 ± 1.13

23.77 ± 1.00

18.61 ± 0.57

28.80 ± 0.34

0.298 ± 1.25

10

24.12 ± 0.47

20.13 ± 0.39

16.03 ± 0.73

26.30 ± 1.04

2.538 ± 0.65

20

19.97 ± 0.26

17.99 ± 0.67

16.65 ± 0.60

21.71 ± 0.28

5.647 ± 0.45

40

21.53 ± 0.42

15.73 ± 0.34

17.40 ± 0.68

22.61 ± 1.00

10.651 ± 0.44

Asthma adult

1

17.71 ± 1.10*

16.74 ± 0.86*

15.21 ± 1.28*

23.53 ± 1.08*

0.239 ± 0.52*

10

14.41 ± 0.20*

13.19 ± 0.93*

12.00 ± 0.57*

15.49 ± 0.26*

1.797 ± 0.40*

20

16.02 ± 1.31*

15.02 ± 1.14*

11.94 ± 0.44*

18.58 ± 0.30*

4.392 ± 0.32*

40

14.78 ± 0.54*

12.82 ± 0.73*

11.61 ± 0.32*

15.69 ± 0.27*

6.821 ± 0.72*