Table 6 Delivered dose (DD, mg)/Emitted dose (ED, mg) for adult breathing patterns. The DD/ED (%) values of the five nebulizers for the asthma adult breathing pattern decreased compared to those for the normal adult breathing pattern at all IgG concentrations

ISO 27427

1

40.48 ± 3.11*

35.15 ± 4.38

25.27 ± 1.12*

29.72 ± 1.78

15.17 ± 0.55

10

40.51 ± 1.74*

37.33 ± 3.22*

26.00 ± 0.60*

31.35 ± 1.63

16.55 ± 0.66*

20

41.23 ± 0.44*

38.32 ± 1.15*

28.23 ± 1.61*

33.33 ± 0.50*

21.30 ± 0.04*

40

31.14 ± 1.53*

32.32 ± 3.22*

26.62 ± 1.26*

31.46 ± 2.81

18.02 ± 1.43*

Normal adult

1

34.50 ± 2.10

34.44 ± 1.56

21.71 ± 0.79

31.54 ± 1.09

17.17 ± 3.35

10

34.43 ± 0.76

29.24 ± 0.78

19.72 ± 0.95

29.13 ± 0.89

14.29 ± 0.73

20

29.13 ± 0.95

26.78 ± 0.97

20.03 ± 0.81

24.82 ± 0.28

16.34 ± 0.44

40

35.37 ± 1.63

23.91 ± 0.40

20.48 ± 1.14

28.03 ± 0.28

15.56 ± 0.57

Asthma adult

1

26.91 ± 2.27*

25.63 ± 0.30

17.76 ± 2.19*

26.16 ± 1.35*

13.42 ± 0.40

10

21.70 ± 0.32*

20.66 ± 0.80*

14.91 ± 0.89*

17.28 ± 0.27*

10.26 ± 0.36*

20

23.36 ± 2.32*

22.71 ± 1.78*

14.83 ± 0.33*

21.09± 0.37*

12.44 ± 0.28*

40

22.59 ± 1.29*

19.26 ± 0.85*

15.40 ± 0.63*

19.20 ± 0.37*

10.51 ± 0.21*