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Table 8 DD/LD (%) for child breathing patterns. The DD/LD (%) values of the five nebulizers for the child asthma breathing pattern decreased compared to those for the normal child breathing pattern at all IgG concentrations

From: Evaluation of antibody drug delivery efficiency via nebulizer in various airway models and breathing patterns

Breathing pattern

IgG conc. (mg/mL)

JN-PARIr (%)

JN-PARIb (%)

SMN-U150 (%)

VMN-SM1 (%)

VMN-SM3 (%)

Normal child

1

13.93 ± 0.40

9.80 ± 1.11

12.77 ± 0.19

21.11 ± 0.17

0.253 ± 0.55

10

11.71 ± 0.71

7.91 ± 0.39

9.66 ± 0.51

13.44 ± 1.04

1.700 ± 0.69

20

12.93 ± 0.93

10.60 ± 1.09

11.77 ± 1.00

14.59 ± 0.22

3.648 ± 0.32

40

10.95 ± 0.26

7.61 ± 0.69

8.96 ± 0.41

13.72 ± 0.93

5.864 ± 0.85

Asthma child

1

10.48 ± 0.43*

6.73 ± 0.18

9.46 ± 0.78*

14.75 ± 0.52*

0.216 ± 0.42*

10

10.04 ± 0.30*

7.06 ± 0.66

7.84 ± 0.29*

12.26 ± 0.98

1.256 ± 0.78*

20

8.93 ± 0.27

6.22 ± 0.43*

7.58 ± 0.34*

10.23 ± 0.34*

2.352 ± 0.20*

40

8.84 ± 0.41*

6.53 ± 0.19

7.50 ± 0.09

9.85 ± 0.14*

4.939 ± 0.30

  1. All data are presented as the mean ± SD values. * p < 0.05, versus the normal child pattern