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Table 9 DD/ED (%) for the child breathing patterns. The DD/ED (%) values of the five nebulizers for the child asthma breathing pattern decreased compared to those for the normal child breathing pattern at all IgG concentrations

From: Evaluation of antibody drug delivery efficiency via nebulizer in various airway models and breathing patterns

Breathing pattern

IgG conc. (mg/mL)

JN-PARIr (%)

JN-PARIb (%)

SMN-U150 (%)

VMN-SM1 (%)

VMN-SM3 (%)

Normal child

1

23.20 ± 1.00

16.53± 1.29

15.29 ± 0.50

23.09 ± 0.38

13.85 ± 0.62

10

18.21 ± 0.32

12.54 ± 0.55

11.08 ± 0.41

14.90 ± 0.83

9.55 ± 0.83

20

20.40 ± 0.61

10.65 ± 1.84

14.53 ± 1.71

16.57 ± 0.51

10.18 ± 0.46

40

17.69 ± 1.42

11.61 ± 1.73

11.94 ± 0.76

16.87 ± 0.80

9.22 ± 1.01

Asthma child

1

17.51 ± 1.24*

10.27 ± 0.32*

11.57 ± 1.74*

16.41 ± 0.62*

12.78 ± 0.79

10

15.74 ± 0.42

11.61 ± 1.65

9.45 ± 0.67*

13.70 ± 1.07

7.15 ± 0.89

20

14.92 ± 0.87*

10.27 ± 0.36*

8.99 ± 0.16*

11.61 ± 0.20*

6.64 ± 0.22*

40

14.91 ± 0.58*

10.81 ± 0.83

9.77 ± 0.44*

12.18 ± 0.07*

7.83 ± 0.35

  1. All data are presented as the mean ± SD values. * p < 0.05, versus the normal child pattern