Fig. 4

EGTI histology score of specimens after renal I/R injury. Renal I/R injury was associated with a marked increase in EGTI histology score (&&, p < 0.01), but amlodipine did not significantly decrease the histology score. I/R injury significantly increased tubular (&, p < 0.05), endothelial (&&, p < 0.01), and glomerular (&&, p < 0.01) scores. Treatment with amlodipine did not lower tubular, endothelial, glomerular, and tubulointerstitial scores. Kruskal–Wallis test and Dunn’s posthoc test were used to compare histological scores. Box and Whisker plots show median, 25 and 75 percentiles, minimum, and maximum values. Median (interquartile range) for EGTI histology score were 0 (0, 1), 7 (5.5, 8.5), and 3 (2.5, 4) in the healthy control group, ischemic control group, and amlodipine-treated group, respectively. Median (interquartile range) for tubular score were 0 (0, 0.5), 2 (1.5, 3), and 1 (0.5, 1) in the healthy control group, ischemic control group, and amlodipine-treated group, respectively. Median (interquartile range) for glomerular score were 0 (0, 0.5), 2 (1.5, 3), and 1 (1, 1.5) in the healthy control group, ischemic control group, and amlodipine-treated group, respectively. Median (interquartile range) for endothelial score were 0 (0, 0.5), 2 (1, 2), and 1 (0.5, 1) in the healthy control group, ischemic control group, and amlodipine-treated group, respectively. Median (interquartile range) for tubulointerstitial score were 0 (0, 1), 1 (1, 2), and 1 (0.5, 1) in the healthy control group, ischemic control group, and amlodipine-treated group, respectively