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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: In diabetic male Wistar rats, quercetin-conjugated superparamagnetic iron oxide nanoparticles have an effect on the SIRT1/p66Shc-mediated pathway related to cognitive impairment

Fig. 3

Effect of QC and QCSPIONs administration on (A) SIRT1, (B) p66Shc, (C) CASP3, and (D) PARP1 mRNA expression levels in the hippocampus of diabetic rats. NDC stands for non-diabetic control, DC for diabetic control, DC + SPION for diabetic treatment using a superparamagnetic iron oxide nanoparticle, DC + QC for diabetic treatment using quercetin, and DC + QCSPION for diabetic treatment using a quercetin-conjugated iron oxide nanoparticle. ** P < 0.01 and *** P < 0.001 and P < 0.0001 versus DC group (one-way ANOVA, Tukey’s multiple comparison tests). Mean values are expressed together with the standard error of the mean (SEM) (n = 5 per group)

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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