Fig. 2

Simulations of plasma concentration-time profiles of ROF and ROF N-oxide after administration of single dose and repeated doses. The predicted and observed plasma concentration-time curves of ROF and ROF N-oxide in healthy subjects at a single dose of 0.5 mg (A), repeated doses of 0.25 mg (B) and 0.5 mg (C), repeated doses of 0.5 mg (D), as well as in COPD patients at repeated doses of 0.25 mg (E) and 0.5 mg (F). The blue open squares (RFO) and red solid up-triangles (RFO N-oxide) denote the clinically observed data