Fig. 3From: Prediction of drug–drug interactions between roflumilast and CYP3A4/1A2 perpetrators using a physiologically-based pharmacokinetic (PBPK) approachThe mean predicted and observed plasma concentration-time profiles of eight CYP3A4 and CYP1A2 perpetrators. Ketoconazole, fluconazole, and rifampicin (A); itraconazole (B); fluvoxamine (C); efavirenz (D); and cimetidine and enoxacin in healthy humans (E)Back to article page