Fig. 4From: Prediction of drug–drug interactions between roflumilast and CYP3A4/1A2 perpetrators using a physiologically-based pharmacokinetic (PBPK) approachSimulations of pharmacokinetics of ROF and ROF N-oxide with ketoconazole (A), fluvoxamine (B), rifampicin (C), enoxacin (D), and cimetidine (E)Back to article page