Fig. 5From: Prediction of drug–drug interactions between roflumilast and CYP3A4/1A2 perpetrators using a physiologically-based pharmacokinetic (PBPK) approachEffect of eight perpetrators on hepatic CYP3A4 and CYP1A2 activity Remaining CYP3A4 activity after inhibition by KET, FLUV, ITR, FLU, and CIM, respectively (A). Remaining CYP1A2 activity after inhibition by FLUV, ENO, and CIM, respectively (B). Increased CYP3A4 activity after induction by RIF and EFA, respectively (C)Back to article page