Fig. 6From: Prediction of drug–drug interactions between roflumilast and CYP3A4/1A2 perpetrators using a physiologically-based pharmacokinetic (PBPK) approachSimulations of AUC ratios and tPDE4i of ROF and ROF N-oxide in the DDIs. AUC ratios change of ROF (A) and ROF N-oxide (B), and tPDE4i change (C) with eight CYP3A3/1A2 perpetrators. Data were shown as geometric mean values and 90% CIBack to article page