Table 2 The inhibition and induction parameters of CYP3A4 and CYP1A2 perpetrators

Ketoconazole (inhibitor, KET) [27]

0.0054

32

Itraconazole (inhibitor, ITR) [28]

0.0013

-

-

Hydroxy-itraconazole [28]^a

0.0023

-

-

Fluconazole (inhibitor, FLU) [29]

16.6

-

-

Fluvoxamine (inhibitor, FLUV)^b

0.52

0.011

-

-

Enoxacin (inhibitor, ENO) [30]

-

110

Cimetidine (inhibitor, CIM) [31, 32]

106

140.7

Rifampicin (inducer, RIF) [28]

-

-

9.0

0.34

Efavirenz (inducer, EFA)^b

-

-

5.2

0.07