Table 1 Calculation result of PFP pharmacokinetic parameters in the blood
Pharmacokinetic Parameters | n | Arithmetic mean(SD) | Coefficient of variation of arithmetic mean (%) | Median | Min – Max | Geometric mean | Coefficient of variation of geometric mean (%) |
|---|---|---|---|---|---|---|---|
Cmax (uL/mL) | 12 | 0.00034475 (0.000132329) | 38.4 | 0.0002864 | 0.0001840–0.0005811 | 0.00032293 | 38.8 |
Tmax (min) | 12 | 2.06 (0.454) | 22.1 | 2.0000 | 1.5–3.0 | 2.01 | 22.1 |
AUClast ((uL/mL)*min) | 12 | 0.000653 (0.0003084) | 47.3 | 0.00063 | 0.00024–0.00134 | 0.000586 | 53.2 |
AUC∞ ((uL/mL)*min) | 10 | 0.001051 (0.0003247) | 30.9 | 0.001015 | 0.00068–0.00178 | 0.001012 | 29.0 |
t1/2 (min) | 10 | 1.68 (0.326) | 19.4 | 1.6500 | 1.2–2.3 | 1.65 | 19.2 |
CL (L/hr) | 10 | 5395.362 (1306.935) | 24.2 | 5669.095 | 3062.01–7061.51 | 5225.103 | 28.6 |
Vss (L) | 10 | 314.812 (89.522) | 28.4 | 318.90 | 192.68–467.41 | 303.006 | 30.2 |