Table 2 PFP pharmacokinetic parameters in the blood by gender
Pharmacokinetic parameters | Gender | n | Arithmetic mean(standard deviation) | Arithmetic coefficient of variation (%) | Median | Min – Max | Geometric mean | Geometric coefficient of variation (%) |
|---|---|---|---|---|---|---|---|---|
Cmax (uL/mL) | Male | 8 | 0.00035852 (0.000134325) | 37.5 | 0.0003376 | 0.0001840–0.0005811 | 0.00033626 | 40.4 |
Female | 4 | 0.00031719 (0.000143485) | 45.2 | 0.00024774 | 0.0002410–0.0005323 | 0.00029785 | 40.3 | |
Tmax (min) | Male | 8 | 2.08 (0.501) | 24.1 | 2.00 | 1.5–3.0 | 2.02 | 23.9 |
Female | 4 | 2.03 (0.411) | 20.3 | 2.05 | 1.5–2.5 | 1.99 | 21.4 | |
AUClast ((uL/mL)*min) | Male | 8 | 0.000691 (0.0003440) | 49.8 | 0.000745 | 0.00024–0.00134 | 0.00061 | 61.3 |
Female | 4 | 0.000575 (0.0002464) | 42.8 | 0.000505 | 0.00036–0.00093 | 0.000541 | 41.1 | |
AUC∞ ((uL/mL)*min) | Male | 6 | 0.001143 (0.0003185) | 27.9 | 0.00105 | 0.00090–0.00178 | 0.001114 | 24.2 |
Female | 4 | 0.000913 (0.0003235) | 35.4 | 0.00079 | 0.00068–0.00139 | 0.000876 | 32.5 | |
t1/2 (min) | Male | 6 | 1.63 (0.308) | 18.8 | 1.60 | 1.2–2.1 | 1.61 | 19.3 |
Female | 4 | 1.75 (0.387) | 22.1 | 1.65 | 1.4–2.3 | 1.72 | 21.2 | |
CL (L/hr) | Male | 6 | 5289.987 (1205.885) | 22.8 | 5624.865 | 3062.01–6418.42 | 5148.346 | 27.5 |
Female | 4 | 5553.425 (1626.382) | 29.3 | 5928.34 | 3295.51–7061.51 | 5342.39 | 34.6 | |
Vss (L) | Male | 6 | 308.275 (97.835) | 31.7 | 283.3 | 214.34–467.41 | 296.335 | 31.1 |
Female | 4 | 324.618 (88.747) | 27.3 | 361.225 | 192.68–383.34 | 313.297 | 33.4 |