Pharmacokinetics and pharmacodynamics of perfluoropropane after intra-venous bolus injection of perflutren lipid microsphere injection (DEFINITY®) in healthy Chinese volunteers

Table 3 Calculation result of PFP pharmacokinetic parameters in expired air

Pharmacokinetic Parameters	n	Arithmetic mean(SD)	Coefficient of variation of arithmetic mean (%)	Median	Min – max	Geometric mean	Coefficient of variation of geometric mean (%)
Ae_0 − 5 (uL)	12	30.455 (18.668)	61.3	24.18	8.932–63.669	25.25	73.4
Ae_{0 − 15.5} (uL)	12	42.041 (24.631)	58.6	34.09	13.887–83.565	35.25	70.9
Ae_{0 − tlast} (uL)	11	25.039 (15.246)	60.9	21.05	7.607–50.920	20.70	74.9
Ae_∞(uL)	12	44.997 (26.010)	57.8	36.89	15.401–90.499	38.01	68.7
CL_lung (L/hr)	12	3203.8 (2407.95)	75.2	2416.50	982–7978	2501.50	84.2
PFP excretion rate¹ (%)	12	47.89 (30.523)	63.7	34.80	15.1–103.7	39.42	74.3
PFP excretion rate² (%)	12	64.45 (41.069)	63.7	46.85	20.4–139.5	53.06	74.3
PFP excretion rate³ (%)	12	38.33 (24.436)	63.8	27.85	12.1–83.0	31.54	74.3

Note: PFP excretion rate: Cumulative excretion volume of PFP (0-15.5 min) in the expired air ÷ PFP dose

ISSN: 2050-6511