Table 4 PFP pharmacokinetic parameters in expired air by gender
Pharmacokinetic parameters | Gender | n | Arithmetic mean (standard deviation) | Arithmetic coefficient of variation (%) | Median | Minimum value-Maximum value | Geometric mean | Geometric coefficient of variation (%) |
|---|---|---|---|---|---|---|---|---|
Ae0 − 5 (uL) | Male | 8 | 23.690 (13.448) | 56.8 | 19.397 | 8.932–48.388 | 20.601 | 61.9 |
Female | 4 | 43.984 (22.131) | 50.3 | 49.278 | 13.711–63.669 | 37.941 | 79.7 | |
Ae0 − 15.5 (uL) | Male | 8 | 33.715 (19.543) | 58 | 28.893 | 13.887–63.435 | 29.171 | 62.7 |
Female | 4 | 58.692 (27.906) | 47.5 | 65.828 | 19.549–83.565 | 51.457 | 73.9 | |
Ae0 − tlast (uL) | Male | 7 | 18.883 (11.045) | 58.5 | 15.564 | 7.607–36.744 | 16.29 | 64.4 |
Female | 4 | 35.812 (16.958) | 47.4 | 40.083 | 12.163–50.920 | 31.488 | 72.6 | |
Ae∞(uL) | Male | 8 | 36.156 (20.445) | 56.5 | 30.631 | 15.401–67.628 | 31.556 | 60.1 |
Female | 4 | 62.680 (29.664) | 47.3 | 69.417 | 21.385–90.499 | 55.161 | 72.2 | |
CLlung (L/hr) | Male | 8 | 2583.1 (2137.52) | 82.7 | 1856 | 982–7318 | 2037.9 | 79.7 |
Female | 4 | 4445.3 (2741.71) | 61.7 | 4122 | 1559–7978 | 3769.1 | 78.6 | |
PFP excretion rate1 (%) | Male | 8 | 34.74 (18.641) | 53.7 | 30.55 | 15.1–65.3 | 30.6 | 58.5 |
Female | 4 | 74.20 (34.942) | 47.1 | 83.7 | 25.7–103.7 | 65.43 | 71.4 | |
PFP excretion rate2 (%) | Male | 8 | 46.75 (25.088) | 53.7 | 41.1 | 20.4–87.9 | 41.18 | 58.5 |
Female | 4 | 99.85 (47.006) | 47.1 | 112.65 | 34.6–139.5 | 88.05 | 71.3 | |
PFP excretion rate3(%) | Male | 8 | 27.79 (14.927) | 53.7 | 24.4 | 12.1–52.3 | 24.47 | 58.5 |
Female | 4 | 59.40 (27.950) | 47.1 | 67.0 | 20.6–83.0 | 52.39 | 71.3 |