Pharmacokinetics and pharmacodynamics of perfluoropropane after intra-venous bolus injection of perflutren lipid microsphere injection (DEFINITY®) in healthy Chinese volunteers

Table 5 Calculation result of Doppler ultrasonic signal parameters

Pharmacodynamic parameters	n	Arithmetic mean (SD)	Coefficient of variation of arithmetic mean (%)	Median	Min – max	Geometric mean	Coefficient of variation of geometric mean (%)
t_max−pd (sec)	12	125.7 (157.44)	125.3	70.5	63–615	91.7	74.3
t₁₀ (sec)	12	359.0 (152.60)	42.5	354	48–618	312.7	73.8
AUC_pd (dB*sec)	12	1076.33 (496.293)	46.1	879.3	541.5–2161.2	988.93	43.6
t_max−pd (sec)	10	71.2 (7.44)	10.4	69	63–87	70.9	10.1
t₁₀ (sec)	10	405.0 (113.57)	28	357	288–618	392.5	26.1
AUC_pd (dB*sec)	10	1050.29 (543.757)	51.8	846.2	541.5–2161.2	950.62	47.3

Note: t₁₀ is the time from the maximum signal to the 10% maximum signal. t₁₀ is based on 30s interval ultrasound signal data. For data points where the Definity correlation enhancement is negative, the valude is set to 0 when calculating AUC_pd

ISSN: 2050-6511