Role of uranium toxicity and uranium-induced oxidative stress in advancing kidney injury and endothelial inflammation in rats

Table 1 Levels of oxidative stress parameters in the serum and uranium content in serum and tissue homogenates of rats from different groups

Biomarkers	NS (n = 10)	U-24h (n = 10)	U-48h (n = 10)	U-72h (n = 10)	F	P
TOS (μmol/L H₂O₂)	11.3 ± 2.91	14.41 ± 3.22	17.07 ± 4.90^a	19.36 ± 6.78^a	6.254	0.003
TAS (mmol/L Trolox)	1.67 ± 0.22	1.48 ± 0.17	1.33 ± 0.26^a	1.25 ± 0.16^a	14.196	<0.001
OSI (arbitrary unit)	0.66 ± 0.19	0.96 ± 0.21	1.35 ± 0.51^a	1.62 ± 0.64^a,b	23.522	<0.001
Tissue U (mg/g)	0.006 ± 0.002	23.55 ± 11.63^a	19.49 ± 5.53^a	14.91 ± 4.87^a,b	30.177	<0.001
Serum U (μg/L)	0.30 ± 0.15	6.29 ± 1.54^a	3.43 ± 1.02^a,b	4.73 ± 1.73^a	40.621	<0.001

Notes ANOVA, One-way ANOVA test. J-T test, Jonckheere-Terpstra test. Pairwise comparison by the Bonfferoni POST-HOC test, ^a vs. NS group, Padj < 0.05; ^b vs. U-24h group, Padj < 0.05. The OxS occurrence was later than the change of uranium content in tissue and serum after uranium exposure, indicating that uranium exposure may be the initiating incentive of oxidative stress

ISSN: 2050-6511