Role of uranium toxicity and uranium-induced oxidative stress in advancing kidney injury and endothelial inflammation in rats

Table 2 Kidney injury and inflammation biomarkers in the sera collected from the four groups of rats

Biomarkers	NS (n = 10)	U-24h (n = 10)	U-48h (n = 10)	U-72h (n = 10)	F	P
Ure (mmol/L)	4.11 ± 0.53	4.84 ± 1.17	6.13 ± 1.58	8.16 ± 3.58^a,b	7.195	0.003
Cre (μmol/L)	21.5 ± 1.8	20.7 ± 3.6	36.7 ± 10.6	66.5 ± 37.3^a,b,c	12.106	<0.001
CysC (μg/L)	0.76 ± 0.12	1.09 ± 0.35^a	1.14 ± 0.15^a	1.19 ± 0.22^a	8.706	<0.001
NGAL (μg/L)	37.5 ± 14.7	91.3 ± 41.9	96.3 ± 56.6^a	111.5 ± 47.0^a	5.402	0.006
CRP (mg/L)	1.53 ± 0.55	2.25 ± 0.80	3.45 ± 0.97^a	5.08 ± 2.40^a,b	11.853	<0.001
Hcy (μmol/L)	9.62 ± 1.61	8.42 ± 1.97	7.96 ± 1.49	7.74 ± 1.33	2.807	0.059
Lp-PLA2 (IU/L)	861 ± 139	685 ± 116^a	6448 ± 103^a	585 ± 85^a	11.366	<0.001

Note According to the POST HOC test of one-way ANOVA (Bonferroni-t test), ^a compared with the NS group, Padj < 0.05; ^b compared with the U-24h group, Padj < 0.05; ^c compared with the U-48h group, Padj < 0.05

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