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Fig. 1 | BMC Pharmacology and Toxicology

Fig. 1

From: Drug-drug interaction assessment based on a large-scale spontaneous reporting system for hepato- and renal-toxicity, and thrombocytopenia with concomitant low-dose methotrexate and analgesics use

Fig. 1

Flow chart for determining crude reporting odds ratios (cRORs) of methotrexate (MTX)-related adverse events and drug-drug interactions between MTX and analgesics. A disproportionality analysis was performed focusing on MTX use and respective adverse events such as hepatotoxicity, renal failure, and thrombocytopenia in cases of rheumatoid arthritis (RA) patients

APAP: acetaminophen; NSAIDs: non-steroidal anti-inflammatory drugs

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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