Fig. 2From: Drug-drug interaction assessment based on a large-scale spontaneous reporting system for hepato- and renal-toxicity, and thrombocytopenia with concomitant low-dose methotrexate and analgesics useCrude reporting odds ratios (cRORs) calculation, 95% confidence intervals (95% CIs) values for each adverse drug event based on 2 × 2 contingency tables. cRORs for respective adverse events were calculated with the 2 × 2 contingency table among cases of rheumatoid arthritis (RA) patientsADE: adverse drug eventBack to article page