Table 1 Crude reporting odds ratio (cROR) for hepatotoxicity, renal failure, and thrombocytopenia

Methotrexate

3.1 (3.01–3.2)

5604.43

1.08 (1.02–1.15)

7.88

1.06 (1–1.11)

4.14

2.37 (2.18–2.56)

474.73

Acetaminophen

1.8 (1.71–1.9)

504.44

1.68 (1.54–1.84)

135.29

1.71 (1.58–1.85)

176.31

1.74 (1.52–1.99)

66.98

Loxoprofen

4.78 (4.2–5.45)

669.61

2.89 (2.23–3.73)

71.02

2.52 (1.96–3.23)

56.13

7.89 (6.16–10.1)

379.3

Diclofenac

2.47 (2.29–2.66)

621.61

2.1 (1.85–2.39)

133.89

2.03 (1.8–2.28)

141.9

2.25 (1.85–2.72)

72.54

Ketoprofen

3.56 (3–4.22)

243.97

2.73 (2.01–3.72)

44.61

2.12 (1.55–2.91)

22.95

3.71 (2.47–5.57)

46.33

Celecoxib

1.75 (1.62–1.88)

231.34

1.6 (1.41–1.81)

55.06

1.39 (1.23–1.57)

28.81

1.9 (1.59–2.26)

51.26

Acetylsalicylic Acid

1.67 (1.56–1.79)

226.96

1.77 (1.59–1.98)

109.51

1.91 (1.74–2.1)

181.67

1.87 (1.58–2.2)

57.89

Indometacin

2.73 (2.26–3.29)

119.37

3.46 (2.64–4.55)

90.55

3.04 (2.34–3.96)

76.05

4.56 (3.17–6.55)

80.67

Sulindac

3.43 (2.71–4.35)

118.17

1.82 (1.09–3.04)

5.45

2 (1.28–3.12)

9.69

3.19 (1.76–5.8)

16.28

Ibuprofen

1.62 (1.47–1.78)

98.41

1.39 (1.17–1.64)

14.14

1.42 (1.22–1.65)

20.24

2.07 (1.67–2.58)

45.21

Etodolac

2.39 (1.98–2.89)

87.92

1.81 (1.28–2.57)

11.39

1.86 (1.36–2.55)

15.46

1.07 (0.53–2.14)

0.04

Tiaprofenic Acid

8.01 (4.01–15.99)

49.3

1.92 (0.26–13.88)

0.43

1.57 (0.22–11.34)

0.2

4.6 (0.63–33.3)

2.76

Naproxen

1.41 (1.28–1.55)

47.49

1.31 (1.11–1.55)

9.86

1.31 (1.12–1.52)

11.94

1.69 (1.35–2.13)

20.7

Zaltoprofen

5.47 (3.04–9.85)

40.72

8 (3.7–17.3)

39.51

1.76 (0.43–7.15)

0.64

7.84 (2.48–24.81)

17.3

Rofecoxib

1.63 (1.38–1.92)

34.57

3.82 (3.18–4.59)

237.2

4.61 (3.95–5.38)

456.32

2.11 (1.46–3.05)

16.61

Meloxicam

1.36 (1.22–1.51)

29.82

1.21 (1–1.47)

3.88

1.21 (1.01–1.44)

4.47

1.27 (0.95–1.7)

2.63

Aceclofenac

3.04 (1.9–4.87)

23.85

1.74 (0.65–4.69)

1.24

2.53 (1.19–5.37)

6.25

5.26 (2.16–12.77)

16.81

Lornoxicam

3.26 (1.92–5.55)

21.4

2.37 (0.88–6.39)

3.08

2.43 (1–5.93)

4.09

5.68 (2.11–15.34)

15.04

Mefenamic Acid

2.87 (1.77–4.65)

20.15

1.74 (0.65–4.69)

1.24

1.79 (0.74–4.34)

1.7

5.26 (2.16–12.77)

16.81

Piroxicam

1.94 (1.43–2.64)

18.99

1.61 (0.93–2.79)

2.94

2.04 (1.31–3.19)

10.34

1.77 (0.79–3.95)

1.97

Oxaprozin

2.42 (1.59–3.7)

17.86

0.58 (0.14–2.31)

0.62

1.43 (0.64–3.2)

0.76

0.69 (0.1–4.9)

0.14

Flurbiprofen

2.31 (1.46–3.63)

13.8

1.92 (0.86–4.32)

2.61

2.93 (1.61–5.36)

13.49

6.21 (3.07–12.54)

33.92