Table 4 Potential drug-drug interaction analysis based on adverse event reports of renal failure 2

Acetaminophen

329

15,488

308.93

0.09 (-0.07–0.25)

N

0

N

1.06

P

1.02

N

Acetylsalicylic acid

174

9,119

247.92

-0.51 (-0.72– -0.3)

N

-0.01

N

0.68

N

0.81

N

Celecoxib

139

8,481

159.36

-0.2 (-0.44–0.04)

N

0

N

0.86

N

0.94

N

Diclofenac

137

6,579

198.91

-0.54 (-0.78– -0.29)

N

-0.01

N

0.67

N

0.83

N

Ibuprofen

71

4,255

81.22

-0.19 (-0.53–0.14)

N

0

N

0.86

N

0.94

N

Meloxicam

60

4,569

82.83

-0.46 (-0.83– -0.1)

N

-0.01

N

0.71

N

0.87

N

Naproxen

58

5,598

134.34

-1.2 (-1.58– -0.83)

N

-0.01

N

0.42

N

0.63

N

Rofecoxib

47

1,265

84.25

-0.84 (-1.25– -0.42)

N

-0.03

N

0.53

N

0.67

N

Loxoprofen

45

1,280

31.55

0.51 (0.08–0.93)

P

0.01

P

1.4

P

1.13

N

Indometacin

33

869

32.01

0.04 (-0.45–0.54)

N

0

N

1

N

1.02

N

Etodolac

19

906

23.73

-0.31 (-0.96–0.34)

N

-0.01

N

0.78

N

0.9

N

Ketoprofen

16

829

29.29

-0.85 (-1.56– -0.15)

N

-0.02

N

0.53

N

0.73

N

Piroxicam

15

431

6.3

1.19 (0.46–1.92)

P

0.02

P

2.37

P

1.37

N

Sulindac

12

439

9.87

0.27 (-0.55–1.09)

N

0

N

1.19

P

1.1

N

Flurbiprofen

7

181

5.95

0.22 (-0.85–1.29)

N

0.01

P

1.14

P

1.07

N

Ketorolac

6

219

8.04

-0.39 (-1.55–0.76)

N

-0.01

N

0.72

N

0.87

N

Oxaprozin

4

159

2.08

0.8 (-0.61–2.22)

N

0.01

P

2.1

P

1.4

N

Mefenamic acid

4

129

1.69

1.04 (-0.37–2.45)

N

0.02

P

2.8

P

1.39

N

Aceclofenac

3

134

6.04

-0.9 (-2.53–0.73)

N

-0.02

N

0.48

N

0.72

N

Tenoxicam

3

40

2.95

0.02 (-1.61–1.65)

N

0

N

0.97

N

1.01

N

Acemetacin

2

46

0.74

1.01 (-0.99–3.01)

N

0.03

P

2.68

P

1.61

N

Fenoprofen

2

8

0.1

2.05 (0.05–4.05)

P

0.25

P

–

N

2.38

N

Lornoxicam

1

93

5.15

-1.91 (-4.74–0.91)

N

-0.04

N

0.19

N

0.36

N

Zaltoprofen

1

55

1.56

-0.46 (-3.29–2.37)

N

-0.01

N

0.62

N

0.83

N

Suprofen

1

1

0.01

1.55 (-1.28–4.38)

N

1

P

–

N

2

N